The nature of phages was a matter of dispute, which was resolved in 1940, and it was continued to develop their activity and application in the Soviet Union and Eastern Europe. Bacteriophages were rst employed in 1919 to treat bacterial illnesses caused by Citrobacter, Enterobacter, and Pseudomonas. Bacteriophages range in complexity from simple spherical viruses with genome sizes of less than 5 kbp to complicated viruses with genome sizes surpassing 280 kbp. They have two signicant parts, head and tail, and are made up of numerous copies of more than 40 distinct proteins. Bacteriophages have been demonstrated to bind with receptors in the walls of both grampositive and gram-negative bacteria, ranging from peptide sequences to polysaccharide moieties. Depending on the type of phage and the physiological state of the bacterium, the life cycle may diverge into the lytic cycle or lysogenic cycle. Lytic-lysogenic switch depends on a variety of inducing factors. Bacteriophage therapy can be administered via several routes, but parenteral routes are the most effective. Auto-dosing, single-dose potential, lack of cross-resistance with antibiotics, etc., are several advantages of phage therapy over antibiotic treatment. Bacteriophages are attracting much attention because of their potential advantages and wide applications as antibacterial agents, diagnostic technologies, phage-based products, and biocontrol agents. They also have several applications in the food industry, agriculture/crop, farm animal and bee protection, environmental, and biosensor development.
Dr. Ranjan Singh did his M.Sc. in Microbiology from R.D. University, Jabalpur, M.P., India in 2006 and Ph.D. in Microbiology from R.M.L. Avadh University, Ayodhya, U.P., India in 2011. He is currently working as Associate Professor in the Department of Microbiology (Faculty of Sciences), Dr. Ram Manohar Lohia Avadh University, Ayodhya, Uttar Pradesh, India. He has more than 11 years of working experience in teaching and industry. He has more than 14 years of research experience. He has published many international research articles, book chapters and books. His area of research interest is Applied Microbiology and Biotechnology and Environmental Microbiology. He has been awarded one Research Project by the Higher Education Department, Government of Uttar Pradesh, Lucknow, U.P., India on Bioremediation of Distillery Efuent using microorganism. Mr. Prashant Singh is a research scholar in Microbiology from R.M.L. Avadh University, Ayodhya, U.P., India with research interests spanning environmental microbiology, microbial ecology, antimicrobial resistance, and applied biotechnology. Mr. Singh's research work focuses on understanding microbial diversity and function in natural and anthropogenic environments, with particular emphasis on water and environmental microbiology, public health relevance, and sustainable microbial applications. He has been involved in eld-based sampling, laboratory analysis, and interdisciplinary research approaches integrating microbiology with environmental science. He has authored and contributed to more than 14 research and review articles, scientic communications, also published various books in the eld of life sciences and has participated in many national and international scientic/ academic activities.
Volume-1 Preface Chapter 1. FUNDAMENTALS OF BACTERIOPHAGES Chapter 2. MORPHOLOGY AND CLASSIFICATION Chapter 3. GENOMIC ARCHITECTURE AND EVOLUTION Chapter 4. LIFE CYCLES OF BACTERIOPHAGES Chapter 5. HOST-PHAGE INTERACTIONS Chapter 6. ISOLATION AND PROPAGATION OF BACTERIOPHAGES Chapter 7. CHARACTERIZATION AND VISUALIZATION TECHNIQUES Chapter 8. STORAGE, PRESERVATION, AND FORMULATION Chapter 9. PHAGE THERAPY: HISTORY, REVIVAL, AND SCOPE Chapter 10. PHAGE THERAPY AGAINST MULTIDRUG-RESISTANT BACTERIA Chapter 11. PHAGE-DERIVED ANTIBACTERIAL ENZYMES Bibliography Index Volume-2 Preface Chapter 12. ROLE OF PHAGES IN NATURAL ECOSYSTEMS Chapter 13. BACTERIOPHAGES IN AGRICULTURE Chapter 14. BACTERIOPHAGES IN FOOD SAFETY AND PROCESSING Chapter 15. WASTEWATER AND BIOREMEDIATION APPLICATIONS Chapter 16. PHAGE DISPLAY TECHNOLOGY Chapter 17. GENETIC ENGINEERING USING PHAGES Chapter 18. PHAGES IN DIAGNOSTICS AND BIOSENSING Chapter 19. CHALLENGES, RISKS, AND BIOETHICS OF PHAGE USE Chapter 20. THE FUTURE OF BACTERIOPHAGE RESEARCH Bibliography Index
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